Since just yesterday I was talking to someone who tried to enslave my comrades and I at gunpoint to dig a hole to bury Angel so that she couldn't come after us anymore and I escaped by shooting him in the stomach, I'd say yes. Though I was planning on getting him on my side, really.

[ Yuri's not bothered by it, oddly. Not at all. ] Obviously there are still going to be consequences if you start something horrible and there's the possibility of getting obliterated from existence. Not just dying, your soul will get wiped.